peptide-r Peptide R, a cyclic peptide, is a specific CXCR4 antagonist - PeptideT Proteins, Peptides, Antibodies, and more Peptide R: A CXCR4 Antagonist with Promising Therapeutic Potential

PeptideC Peptide R, a fascinating cyclic peptide, has emerged as a significant player in scientific research, primarily recognized for its potent activity as a CXCR4 antagonist. This specific characteristic positions Peptide R as a molecule of interest for its ability to profoundly remodel tumor stroma and influence various cellular processes. Composed of seven amino acids linked by peptide bonds, its peculiar structure, including a disulfide bond, contributes to its unique biological functions. The amino acid sequence of Peptide R is often cited as KRRLRKLRGLRR-NH2, highlighting its arginine-rich nature.

The scientific community's interest in Peptide R is underscored by its demonstrated capacity to target the CXCR4 receptor. This receptor plays a crucial role in cell signaling, particularly in the context of inflammation and cancer.Peptide R, a cyclic peptide,is a specific CXCR4 antagonist. Chemical Information. Molecular Weight, 902.1. Formula, C39H59N13O8S2. CAS Number, 1774344-28-3. By acting as a specific CXCR4 antagonist, Peptide R can inhibit the binding of its natural ligand, CXCL12, thereby modulating downstream signaling pathways. Research has shown that Peptide R can inhibit CXCL12-mediated cell migration, ERK phosphorylation, and CXCR4 internalization.Peptide R analogue 10can inhibit CXCL12-mediated cell migration, ERK phosphorylation and CXCR4 internalization. Peptide R analogue 10 can be used in the study ... This targeted action makes it a valuable tool for investigating the role of CXCR4 antagonism in various disease models.

One of the most compelling applications of Peptide R lies in oncology作者：RM Riley·2023·被引用次数：10—PeptideRangeris a flexible, extensively annotated, and intuitive R package that uses a random forest model trained on a diverse data set of thousands of MS .... Studies indicate that Peptide R can impair cell growth and potentiate the efficacy of conventional chemotherapy (CT) and chemo-radiotherapy (RT-CT). Specifically, in colon cancer research, Peptide R has been shown to ameliorate treatment effects by inhibiting cell growth and reversing epithelial-mesenchymal transition (EMT)作者：Y Ji·2023·被引用次数：34—ETRs are widely expressed in the human body, with ETAR primarily expressed in the cardiovascular system and ETBR in the brain. They are .... Its ability to remodel the tumor stroma offers a potential strategy to enhance the delivery and effectiveness of anti-cancer agents2023年12月13日—Peptides:Calculate Indices and Theoretical Physicochemical Properties of Protein Sequences. Includes functions to calculate several .... The potential for Peptide R in cancer research is substantial, with ongoing investigations into its precise mechanisms of action and therapeutic utility.

Beyond its anti-cancer applications, the broader implications of Peptide R's interaction with cellular pathways are being explored作者：S Futaki·2001·被引用次数：2265—In this report, we have shown that not only Tat-(48–60) but also various arginine-richpeptideswere able to translocate through the mouse macrophage membranes.. For instance, the concept of peptide R functions as a competitive inhibitor of ATP binding to specific kinase domains suggests a wider range of potential applications in cellular regulation.Peptide R / CXCR4 Antagonist Furthermore, the exploration of arginine-rich peptides in general has revealed their ability to translocate through cell membranes, opening avenues for targeted delivery of therapeutic payloads.

The development and research surrounding Peptide R are supported by advancements in peptide synthesis and analysisR-CHP | Collagen Hybridizing Peptide, Cy3 Conjugate. The availability of Peptide R TFA, a synthetic form, allows for its use in various experimental settings.Peptide R- - 上海鸿肽生物科技 For optimal storage and stability, Peptide R in its lyophilized form can be preserved for up to 6 months at 0-5°C. After rehydration, solutions are recommended to be kept at +4°C for up to 5 days. The molecular formula of Peptide R is C39H59N13O8S2 with a molecular weight of 902.1, and its CAS number is 1774344-28-3.

It is important to distinguish Peptide R from other related peptides. While the search term "peptide r" might bring up results for other compounds, its primary identity in scientific literature is as a CXCR4 antagonist. For example, Retatrutide is a distinct peptide being developed for metabolic conditions like obesity and type 2 diabetes, and it is not directly related to the CXCR4 antagonist function of Peptide R. Similarly, Peptide T and Peptide C are different molecular entities with their own distinct research areas. The field of peptides is vast, encompassing molecules like collagen hybridizing peptide (CHP) and various proteins, peptides, and antibodies used in research and development.

The ongoing research into Peptide R highlights the dynamic nature of peptide science. Tools like the R package PeptideRanger and the broader Peptides package in R (which can Calculate Indices and Theoretical Physicochemical Properties of Protein Sequences) contribute to the efficient analysis and understanding of these complex moleculesPeptide. The exploration of gastrin-releasing peptide (GRP) and its receptors (GRPR) represents another area within peptide research, though distinct from the specific actions of Peptide R.Structural basis of peptide recognition and activation ...

In summary, Peptide R stands out as a significant CXCR4 antagonist with demonstrated potential in cancer therapy and a broader scope for influencing cellular processes. Its unique structure and specific mechanism of action continue to be a focus of intensive scientific inquiry, promising further insights into its therapeutic applicationsTo investigate the role of CXCR4 antagonism in potentiating colon cancer standard therapy, the new peptide CXCR4 antagonistPeptide R(Pep R) was employed..