viola biflora cyclic peptide 479.175 Viola odorata - collagen-peptide-protein Viola Unveiling the Secrets of Viola Biflora Cyclic Peptide 479.175: A Deep Dive into Plant-Derived Bioactives

vilgain-grass-fed-collagen-peptides The intricate world of natural products continues to unveil fascinating molecules with significant biological potential. Among these, cyclic peptides derived from plants are gaining considerable attention for their diverse pharmacological properties. This article delves into the specific realm of Viola biflora cyclic peptide 479.175, exploring its origins, structural characteristics, and the broader implications of cyclotides found within the Viola genusThe alpine violet, Viola biflora, is a rich source of novel ....

Viola biflora, also known as the Yellow Wood Violet or Two-flowered Violet, has emerged as a significant source of these remarkable peptides. Research by Herrmann and colleagues has consistently highlighted Viola biflora as a rich repository of cyclotides, demonstrating their potent cytotoxicity. These findings underscore the plant's ecological role, likely participating in plant defense mechanisms. This species, belonging to the Violaceae family, is not alone in its production of these compounds; in fact, violets are the only plant family found to ubiquitously contain cyclotides in every sampled species to date, as noted by Hellinger in 2015作者：U Göransson·1999·被引用次数：226—Seven novel macrocyclic polypeptides, designated as varvpeptidesB-H, have been isolated from the aerial parts ofViolaarvensis..

Cyclotides themselves are a unique class of plant-derived mini-proteins characterized by a distinctive circular structure and a conserved arrangement of six cysteine residues. These residues form a cyclic cystine knot (CCK motif), a robust structural feature that contributes to their remarkable stability. Typically, these cyclic peptides are composed of 29-37 amino acids, with the cyclic peptide nature arising from the head-to-tail cyclization of the peptide backbone. The specific molecule, Viola biflora cyclic peptide 479.175, refers to a particular cyclotide isolated from this plant, with "479.175" likely representing its molecular mass or a specific identifier in a database.

The biological activities of cyclotides are extensive and continue to be an active area of research.The alpine violet, Viola biflora, is a rich source of novel ... Beyond their insecticidal effects, studies have demonstrated their potential as cytotoxic agents, with Viola biflora cyclic peptide vibi-D exhibiting moderate levels of activity against a human lymphoma cell line. Furthermore, cyclotides have shown promise as anti-HIV, antimicrobial, and even haemolytic agents. The research on Viola odorata L.Isolation and characterization of cyclotides from the leaves of ..., for instance, reveals its production of a plethora of structurally stable peptides with known pharmacological properties, further emphasizing the therapeutic potential within the Viola genus作者：L Aslam·2021·被引用次数：8—Cyclotides are true gene products characterized by the presence of six conserved cysteine residues and knotted arrangement of three disulfide bonds..

The structural elucidation of these peptides is crucial for understanding their function作者：A Herrmann·2008·被引用次数：177—In this study, we show that the alpine violetViola biflora(Violaceae) is a rich source of cyclotides.. For example, studies have focused on the primary and 3-D modelled structures of cyclotides, revealing the intricate cyclic cystine knot that underpins their stabilityThispeptideiscyclic. The start position was chosen by similarity to OAK1 (kalata-B1) for which the DNA sequence is known. Curated .... The amino acid sequence of specific cyclotides, such as cyclotide vibi-I and cyclotide vibi-B from Viola biflora, has been determined, with sequences often being curated by similarity to known cyclotides like OAK1 (kalata-B1). The complexity of these molecules is further highlighted by investigations into variations in cyclotide expression across different viola species, such as the native Australian violet, Viola hederacea.

In conclusion, Viola biflora cyclic peptide 479.LC-MS/MS identification and structural characterization of ...175 represents a fascinating example of the bioactive compounds produced by the plant kingdom.Probably participates in a plant defense mechanism. Has moderate levels of cytotoxic activity, active against a human lymphoma cell line with an IC50 of >30 ... The discovery and characterization of cyclotides from Viola biflora and other Viola species continue to expand our understanding of natural product chemistry and offer promising avenues for the development of novel therapeutic agents. The inherent stability and diverse bioactivities of these cyclic peptides make them compelling subjects for ongoing scientific exploration.