ip10 peptide CXCL10 - peptide-pour-maigrir CXCL10, also known as interferon γ-induced protein 10 kDa (IP-10 The Multifaceted Role of IP-10 Peptide in Immunity and Disease

peptides-eye-patches The ip10 peptide, also widely recognized as CXCL10 or Interferon-gamma inducible Protein 10kDa, is a significant player in the complex landscape of the human immune system. This pro-inflammatory cytokine belongs to the CXC chemokine family and is secreted by various cell types, including monocytes, fibroblasts, and endothelial cells, particularly in response to stimuli like Interferon-gamma (IFN-γ) and Lipopolysaccharide (LPS). Its intricate functions extend to regulating both innate and adaptive immunity by influencing a range of immune cells such as T cells, natural killer cells, dendritic cells, macrophages, and B cells. The CXCL10 molecule exerts its biological effects primarily through binding to its specific receptor, CXCR3.CXCL10, also known as interferon γ-induced protein 10 kDa (IP-10), is a cytokine belonging to the CXC chemokine family. CXCL10 exerts its biological effects ...

Understanding the Structure and Function of IP-10

The structure of IP-10 has been a subject of extensive research, with crystal structures of its oligomeric forms being determined, providing detailed models of the IP-10 chainHuman CXCL10 peptide (DAG331). This chemokine receptor specific for CXCR3 plays a crucial role in chemotaxis, differentiation, and activation of peripheral immune cells.Pro-inflammatory cytokinethat is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells. The CXCR3 binding chemokine IP-10/CXCL10 has been found to be a potent inhibitor of angiogenesis, a process vital for blood vessel formation. Furthermore, a truncated derivative of IP-10, known as IP-10p, has demonstrated the ability to activate CXCR3 and, importantly, IP-10p provides a novel therapeutic agent that inhibits endothelial cell function, thus allowing for the modulation of angiogenesis.IP10 Protein In fact, research indicates that IP-10 is able to inhibit endothelial cell motility, vessel formation, and induce vessel regression. This characteristic highlights the potential of ip10 peptide derivatives in therapeutic applications.

IP-10 as a Biomarker and its Role in Disease

The significance of IP-10 extends beyond its direct immune functions; it is also recognized as an important factor in various autoimmune diseases. Conditions such as Hashimoto's thyroiditis, Graves' disease, and Type 1 diabetes mellitus have been linked to IP-10's involvement. Consequently, IP-10 is an important factor in autoimmune diseases, and its levels can serve as a crucial biomarker. Specifically, IP-10 is a chemokine secreted in response to IFN-γ playing a major role in the activation and regulation of inflammatory and immune responses within the body, making it a valuable indicator of host immune response. The importance of IP-10 as a biomarker of host immune response is continuously being explored in the context of infectious diseases as well, where it helps elucidate pathogenesis and identify potential therapeutic targets.

Availability and Applications of Recombinant IP-10

For research and therapeutic development, recombinant human CXCL10/IP10 protein and related peptides are commercially available.An IP-10 (CXCL10)-Derived Peptide Inhibits Angiogenesis These include products like Recombinant human CXCL10/IP10 protein (Active), which is a full-length human protein with high purity and low endotoxin levelsRecombinant human CXCL10/IP10 protein(Active) is a Human Full Length protein, in the 22 to 98 aa range with >=95% purity, <= 0.005 EU/μg endotoxin level.. Other offerings include Invitrogen Human CXCL10 (IP-10) Protein and Recombinant Human IP10 Protein, often characterized by their purity and validated applications. These recombinant proteins, including Recombinant Human IP10 Protein (Fc Tag) and Recombinant Rat CXCL10/IP10 Protein, are essential tools for studying the biological activities of CXCL10, such as its role in inflammation and its potential antitumor effectsThe CXCR3 Binding Chemokine IP-10/CXCL10: Structure and .... The availability of CXCL10 Antibody Blocking Peptide also aids in research by allowing for specific inhibition of CXCL10 activity.An IP-10 (CXCL10)-Derived Peptide Inhibits Angiogenesis Researchers can also find Ip-10 (CXCL10) purity was determined to be greater than 97%, indicating high quality for experimental use. The compound Ip5/ip10 ipam high quality with high purity 99+ peptide also points to the availability of high-purity peptides for research.

In summary, the ip10 peptide is a critical mediator of immune responses, implicated in both physiological processes and pathological conditions. Its ability to modulate angiogenesis and its role as a biomarker in autoimmune and infectious diseases underscore its multifaceted importance in biological research and potential therapeutic strategiesArticle Crystal Structures of Oligomeric Forms of the IP-10 ....